Trace elements: role in the development of severe forms of COVID-19 and the possibility of correction

The COVID-19 pandemic has set tasks for health professionals, in particular, related to the rapid diagnosis of the disease and the provision of medical care to patients with a new coronavirus infection. All over the world, scientific work is being carried out on the study of the clinical and epidemiological characteristics of the dis-ease, the development of new means of its prevention and treatment. Epidemiological studies have identified a number of physiological and other factors that increase the risk of developing severe forms of the disease. Among them: old age, as well as concomitant diseases, including diabetes mellitus, cardiovascular diseases, chronic kidney disease and others. Changes in the balance of trace elements (ME) are considered as a risk factor for the development of severe forms of COVID-19. It is especially important that this factor can potentially be influenced, especially given the potential for replenishing the ME deficit in patients with COVID-19 for the purpose of early recovery and faster rehabilitation.Copyright © 2022 Tomsk Polytechnic University, Publishing House. All rights reserved.

Prospects for studying the role of some essential and toxic trace elements in the pathogenesis of COVID-19

Introduction. Factors affecting the severity of the course of a new coronavirus infection remain unexplored to the end Aim. To study the factors associated with the transition of COVID-19 from moderate to severe form of the disease in patients undergoing inpatient treatment Materials and methods. The diagnosis of COVID-19-associated pneumonia was made by a clinician on the basis of PCR test data and an up-to-date chest CT scan. A total of 195 consecutively recruited patients were examined. The average age of the surveyed was 54 (12.1) years. Results. Significantly more patients with severe coronavirus infection at the time of hospitalization were active tobacco smokers (33 (29.73%) vs 67 (79.6%);p < 0.002) and had a BMI consistent with pre-obesity/obesity (42 (37.84%) vs 44 (52.38%);p = 0.027). In patients with severe COVID-19, a significantly higher content of leukocytes was noted in the complete blood count (6.054 (2.813) vs 7.307 (4.707);p = 0.021). The groups also differed significantly in the content of micro-and macroelements. The imbalance of minerals revealed in our study is published for the first time, because. The study of the content of Al, B, Li, Co, Sr and Si in patients with COVID-19 was not carried out. Conclusion. The revealed changes in the microelement status require further study to confirm their significance in the development of a severe form of a new coronavirus infection in patients. © 2022, Remedium Group Ltd. All rights reserved.

Prospects for studying the role of some essential and toxic trace elements in the pathogenesis of COVID-19

Introduction. Factors affecting the severity of the course of a new coronavirus infection remain unexplored to the end Aim. To study the factors associated with the transition of COVID-19 from moderate to severe form of the disease in patients undergoing inpatient treatment Materials and methods. The diagnosis of COVID-19-associated pneumonia was made by a clinician on the basis of PCR test data and an up-to-date chest CT scan. A total of 195 consecutively recruited patients were examined. The average age of the surveyed was 54 (12.1) years. Results. Significantly more patients with severe coronavirus infection at the time of hospitalization were active tobacco smokers (33 (29.73%) vs 67 (79.6%);p < 0.002) and had a BMI consistent with pre-obesity/obesity (42 (37.84%) vs 44 (52.38%);p = 0.027). In patients with severe COVID-19, a significantly higher content of leukocytes was noted in the complete blood count (6.054 (2.813) vs 7.307 (4.707);p = 0.021). The groups also differed significantly in the content of micro-and macroelements. The imbalance of minerals revealed in our study is published for the first time, because. The study of the content of Al, B, Li, Co, Sr and Si in patients with COVID-19 was not carried out. Conclusion. The revealed changes in the microelement status require further study to confirm their significance in the development of a severe form of a new coronavirus infection in patients. © 2022, Remedium Group Ltd. All rights reserved.

Trace elements: role in the development of severe forms of COVID-19 and the possibility of correction

The COVID-19 pandemic has set tasks for health professionals, in particular, related to the rapid diagnosis of the disease and the provision of medical care to patients with a new coronavirus infection. All over the world, scientific work is being carried out on the study of the clinical and epidemiological characteristics of the dis-ease, the development of new means of its prevention and treatment. Epidemiological studies have identified a number of physiological and other factors that increase the risk of developing severe forms of the disease. Among them: old age, as well as concomitant diseases, including diabetes mellitus, cardiovascular diseases, chronic kidney disease and others. Changes in the balance of trace elements (ME) are considered as a risk factor for the development of severe forms of COVID-19. It is especially important that this factor can potentially be influenced, especially given the potential for replenishing the ME deficit in patients with COVID-19 for the purpose of early recovery and faster rehabilitation. © 2022 Tomsk Polytechnic University, Publishing House. All rights reserved.

Prospects for studying the role of some essential and toxic trace elements in the pathogenesis of COVID-19

Despite the development and implementation of vaccines in various countries of the world, COVID-19 remains a significant medical and social problem. This is directly related to the characteristic feature of SARS-CoV-2 to form new strains, which reduces the effectiveness of vaccination. In connection with the foregoing, the priority in the prevention of COVID-19 is to improve and maintain the normal functioning of the human immune system. Recently, more and more scientists have noted the significant role of micronutrients in ensuring immune function. However, most research focuses on micronutrients such as zinc, selenium, iron and copper, while it is known that the balance of micronutrients depends on all its constituents. Consequently, any change in the content of one mineral substance can affect the level of others, leading to an imbalance of trace elements in the body. The aim of this work was to analyze literature data on less studied microelements in the context of the COVID-19 pandemic, both essential and toxic, that can affect the state of the immune system and, as a result, the incidence and risk of complications and adverse outcomes in COVID-19. An analysis of the literature on the effect of manganese, chromium, iodine, cadmium, mercury, lead, arsenic and lithium on human antiviral protection, including in the case of a disease caused by SARS-CoV-2, showed that the determination of the microelement status, taking into account the above microelements and, with necessary, the appointment of preparations containing minerals is promising for the purpose of prevention and as an additional therapy for COVID-19. © 2022, Remedium Group Ltd. All rights reserved.